Structural and Functional Analyses of the Shedding Protease ADAM17 in HoxB8-Immortalized Macrophages and Dendritic-like Cells

A disintegrin and metalloproteinase (ADAM) 17 has been implicated in many shedding processes. Major substrates of ADAM17 are TNF-α, IL-6R, and ligands of the epidermal growth factor receptor. The essential role of the protease is emphasized by the fact that ADAM17 deficiency is lethal in mice. To st...

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Detalles Bibliográficos
Autores principales: Cabron, Anne-Sophie, El azzouzi, Karim, Boss, Melanie, Arnold, Philipp, Schwarz, Jeanette, Rosas, Marcela, Dobert, Jan Philipp, Pavlenko, Egor, Schumacher, Neele, Renné, Thomas, Taylor, Philip R., Linder, Stefan, Rose-John, Stefan, Zunke, Friederike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2018
Materias:
Molecular and Structural Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215251/
https://www.ncbi.nlm.nih.gov/pubmed/30355783
http://dx.doi.org/10.4049/jimmunol.1701556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215251/
https://www.ncbi.nlm.nih.gov/pubmed/30355783
http://dx.doi.org/10.4049/jimmunol.1701556

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