ENPP1 enzyme replacement therapy improves blood pressure and cardiovascular function in a mouse model of generalized arterial calcification of infancy

Generalized arterial calcification of infancy (GACI) is a rare, life-threatening disorder caused by loss-of-function mutations in the gene encoding ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), which normally hydrolyzes extracellular ATP into AMP and pyrophosphate (PP(i)). The disease...

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Detalles Bibliográficos
Autores principales: Khan, Tayeba, Sinkevicius, Kerstin W., Vong, Sylvia, Avakian, Arlen, Leavitt, Markley C., Malanson, Hunter, Marozsan, Andre, Askew, Kim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215426/
https://www.ncbi.nlm.nih.gov/pubmed/30158213
http://dx.doi.org/10.1242/dmm.035691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215426/
https://www.ncbi.nlm.nih.gov/pubmed/30158213
http://dx.doi.org/10.1242/dmm.035691

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