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A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies
Huntington's disease (HD) is a monogenic, progressive, neurodegenerative disorder with currently no available treatment. The Libechov transgenic minipig model for HD (TgHD) displays neuroanatomical similarities to humans and exhibits slow disease progression, and is therefore more powerful than...
Autores principales: | Askeland, Georgina, Rodinova, Marie, Štufková, Hana, Dosoudilova, Zaneta, Baxa, Monika, Smatlikova, Petra, Bohuslavova, Bozena, Klempir, Jiri, Nguyen, The Duong, Kuśnierczyk, Anna, Bjørås, Magnar, Klungland, Arne, Hansikova, Hana, Ellederova, Zdenka, Eide, Lars |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215428/ https://www.ncbi.nlm.nih.gov/pubmed/30254085 http://dx.doi.org/10.1242/dmm.035949 |
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