Pancreatic Islet-Autonomous Insulin and Smoothened-Mediated Signaling Modulate Identity Changes of Glucagon(+) α-Cells

The mechanisms restricting regeneration and maintaining cell identity following injury are poorly characterized in higher vertebrates. Upon β-cell loss, 1–2% of the glucagon-producing α-cells spontaneously engage in insulin production in mice. Here we explore the mechanisms inhibiting α-cell plastic...

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Detalles Bibliográficos
Autores principales: Cigliola, Valentina, Ghila, Luiza, Thorel, Fabrizio, van Gurp, Léon, Baronnier, Delphine, Oropeza, Daniel, Gupta, Simone, Miyatsuka, Takeshi, Kaneto, Hideaki, Magnuson, Mark A., Osipovich, Anna B., Sander, Maike, Wright, Christopher V. E., Thomas, Melissa K., Furuyama, Kenichiro, Chera, Simona, Herrera, Pedro L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215453/
https://www.ncbi.nlm.nih.gov/pubmed/30361701
http://dx.doi.org/10.1038/s41556-018-0216-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215453/
https://www.ncbi.nlm.nih.gov/pubmed/30361701
http://dx.doi.org/10.1038/s41556-018-0216-y

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