The novel ghrelin receptor inverse agonist PF-5190457 administered with alcohol: preclinical safety experiments and a phase 1b human laboratory study

Rodent studies indicate that ghrelin receptor blockade reduces alcohol consumption. However, no ghrelin receptor blockers have been administered to heavy drinking individuals. Therefore, we evaluated the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and behavioral effects of a n...

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Detalles Bibliográficos
Autores principales: Lee, Mary R., Tapocik, Jenica D., Ghareeb, Mwlod, Schwandt, Melanie L., Dias, Alexandra A., Le, April N., Cobbina, Enoch, Farinelli, Lisa A., Bouhlal, Sofia, Farokhnia, Mehdi, Heilig, Markus, Akhlaghi, Fatemeh, Leggio, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215751/
https://www.ncbi.nlm.nih.gov/pubmed/29728704
http://dx.doi.org/10.1038/s41380-018-0064-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215751/
https://www.ncbi.nlm.nih.gov/pubmed/29728704
http://dx.doi.org/10.1038/s41380-018-0064-y

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