Cargando…

Transcriptome–pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS

Sporadic amyotrophic lateral sclerosis (sALS) is the most common form of ALS, however, the molecular mechanisms underlying cellular damage and motor neuron degeneration remain elusive. To identify molecular signatures of sALS we performed genome-wide expression profiling in laser capture microdissec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krach, Florian, Batra, Ranjan, Wheeler, Emily C., Vu, Anthony Q., Wang, Ruth, Hutt, Kasey, Rabin, Stuart J., Baughn, Michael W., Libby, Ryan T., Diaz-Garcia, Sandra, Stauffer, Jennifer, Pirie, Elaine, Saberi, Shahram, Rodriguez, Maria, Madrigal, Assael A., Kohl, Zacharias, Winner, Beate, Yeo, Gene W., Ravits, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215775/ https://www.ncbi.nlm.nih.gov/pubmed/29881994 http://dx.doi.org/10.1007/s00401-018-1870-7

Ejemplares similares

Sporadic ALS has compartment-specific aberrant exon splicing and altered cell–matrix adhesion biology
por: Rabin, Stuart J., et al.
Publicado: (2010)

TDP-43 and ubiquitinated cytoplasmic aggregates in sporadic ALS are low frequency and widely distributed in the lower motor neuron columns independent of disease spread
por: Bodansky, Aaron, et al.
Publicado: (2010)

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization
por: Aladesuyi Arogundade, Olubankole, et al.
Publicado: (2021)

Pathological TDP-43 changes in Betz cells differ from those in bulbar and spinal α-motoneurons in sporadic amyotrophic lateral sclerosis
por: Braak, Heiko, et al.
Publicado: (2016)

Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis
por: Krach, Florian, et al.
Publicado: (2022)

Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses
por: Kapeli, Katannya, et al.
Publicado: (2016)

TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis
por: Williams, Stephanie M., et al.
Publicado: (2017)

TDP-43 Is Not a Common Cause of Sporadic Amyotrophic Lateral Sclerosis
por: Guerreiro, Rita J., et al.
Publicado: (2008)

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis
por: Cykowski, Matthew D., et al.
Publicado: (2018)

CHMP2B regulates TDP-43 phosphorylation and cytotoxicity independent of autophagy via CK1
por: Deng, Xue, et al.
Publicado: (2021)

TDP-43 Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP
por: Ferrer, Isidro, et al.
Publicado: (2021)

Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy()
por: Cortese, Andrea, et al.
Publicado: (2014)

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
por: Melamed, Ze’ev, et al.
Publicado: (2019)

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
por: Polymenidou, Magdalini, et al.
Publicado: (2011)

Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo
por: Kawamata, Hibiki, et al.
Publicado: (2017)

Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment
por: Martínez-González, Loreto, et al.
Publicado: (2020)

An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington’s disease patient neurons
por: Krach, Florian, et al.
Publicado: (2022)

Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration
por: Regensburger, Martin, et al.
Publicado: (2020)

Heterogeneity of cerebral TDP-43 pathology in sporadic amyotrophic lateral sclerosis: Evidence for clinico-pathologic subtypes
por: Takeuchi, Ryoko, et al.
Publicado: (2016)

Spinal Cord and Motor Neuron TDP-43 Pathology in a Sporadic Inclusion Body Myositis Patient
por: Cathcart, Sahara J, et al.
Publicado: (2020)

Tau and TDP-43 synergy: a novel therapeutic target for sporadic late-onset Alzheimer’s disease
por: Latimer, Caitlin S., et al.
Publicado: (2021)

TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients
por: Martinez-Gonzalez, Loreto, et al.
Publicado: (2023)

Macro-CK and CK-BB Contributing to Sham CK-MB Elevation
por: Wada, Yuki, et al.
Publicado: (2017)

Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis
por: Ditsworth, Dara, et al.
Publicado: (2017)

Crosstalk between CRISPR-Cas9 and the human transcriptome
por: Smargon, Aaron A., et al.
Publicado: (2022)

AAV9 supports wide-scale transduction of the CNS and TDP-43 disease modeling in adult rats
por: Jackson, Kasey L, et al.
Publicado: (2015)

Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease
por: Kohl, Zacharias, et al.
Publicado: (2010)

Utility of CK8, CK10, CK13, and CK17 in Differential Diagnostics of Benign Lesions, Laryngeal Dysplasia, and Laryngeal Squamous Cell Carcinoma
por: Boricic, Novica, et al.
Publicado: (2022)

Nxf1 Natural Variant E610G Is a Semi-dominant Suppressor of IAP-Induced RNA Processing Defects
por: Concepcion, Dorothy, et al.
Publicado: (2015)

An Immunohistochemical Expression of CK5/6, CK7, and CK20 on Cell Blocks in Metastatic Cervical Lymphadenopathy
por: Kaur, Amanpreet, et al.
Publicado: (2022)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
por: Pickles, Sarah, et al.
Publicado: (2022)

Rethinking to riluzole mechanism of action: the molecular link among protein kinase CK1δ activity, TDP-43 phosphorylation, and amyotrophic lateral sclerosis pharmacological treatment
por: Bissaro, Maicol, et al.
Publicado: (2019)

Invasive Lobular Carcinomas Do Not Express Basal Cytokeratin Markers CK5/6, CK14 and CK17
por: Khilko, Natalya, et al.
Publicado: (2010)

The Multiple Personalities of the Regulatory Subunit of Protein Kinase CK2: CK2 Dependent and CK2 Independent Roles Reveal a Secret Identity for CK2β
por: Bibby, Ashley C., et al.
Publicado: (2005)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
por: Zhang, Lumi, et al.
Publicado: (2020)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

CK 20‐positive and CK 7‐negative Merkel cell carcinoma of the cheek
por: Rai, Manoj Ponadka, et al.
Publicado: (2018)

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders
por: Baier, Andrea, et al.
Publicado: (2022)

Detection and quantification of novel C‐terminal TDP‐43 fragments in ALS‐TDP
por: Feneberg, Emily, et al.
Publicado: (2021)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ih7qglalma1uocuol2i1it1msv