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Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

Hepatocellular carcinoma (HCC) accounts for a large proportion of liver cancer cases and has an extremely poor prognosis. Therefore, novel innovative therapies for HCC are strongly desired. As gene therapy tools for HCC, 2 hepatic transcription factors (TF), HNF4A and HNF1A, have been used to suppre...

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Detalles Bibliográficos
Autores principales: Takashima, Yasuo, Horisawa, Kenichi, Udono, Miyako, Ohkawa, Yasuyuki, Suzuki, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215883/
https://www.ncbi.nlm.nih.gov/pubmed/30220099
http://dx.doi.org/10.1111/cas.13798