Cargando…

Azithromycin treatment modifies airway and blood gene expression networks in neutrophilic COPD

Long-term, low-dose azithromycin reduces exacerbation frequency in chronic obstructive pulmonary disease (COPD), yet the mechanism remains unclear. This study characterised genome-wide gene expression changes in patients with neutrophilic COPD following long-term, low-dose azithromycin treatment. Pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Baines, Katherine J., Wright, Thomas K., Gibson, Peter G., Powell, Heather, Hansbro, Philip M., Simpson, Jodie L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215914/ https://www.ncbi.nlm.nih.gov/pubmed/30406125 http://dx.doi.org/10.1183/23120541.00031-2018

Ejemplares similares

The Effect of Azithromycin in Adults with Stable Neutrophilic COPD: A Double Blind Randomised, Placebo Controlled Trial
por: Simpson, Jodie L., et al.
Publicado: (2014)

Influence of Age, Past Smoking, and Disease Severity on TLR2, Neutrophilic Inflammation, and MMP-9 Levels in COPD
por: Simpson, Jodie L., et al.
Publicado: (2013)

Peripheral blood eosinophils: a surrogate marker for airway eosinophilia in stable COPD
por: Negewo, Netsanet A, et al.
Publicado: (2016)

Blood Neutrophils In COPD But Not Asthma Exhibit A Primed Phenotype With Downregulated CD62L Expression
por: Lokwani, Ravi, et al.
Publicado: (2019)

Airway β-Defensin-1 Protein Is Elevated in COPD and Severe Asthma
por: Baines, Katherine J., et al.
Publicado: (2015)

Airway monocyte modulation relates to tumour necrosis factor dysregulation in neutrophilic asthma
por: Niessen, Natalie M., et al.
Publicado: (2021)

Haemophilus influenzae Infection Drives IL-17-Mediated Neutrophilic Allergic Airways Disease
por: Essilfie, Ama-Tawiah, et al.
Publicado: (2011)

Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study
por: Lokwani, Ravi, et al.
Publicado: (2019)

Sputum colour can identify patients with neutrophilic inflammation in asthma
por: Pabreja, Kavita, et al.
Publicado: (2017)

Efficacy of azithromycin in severe asthma from the AMAZES randomised trial
por: Gibson, Peter G., et al.
Publicado: (2019)

Severity of Lung Function Impairment Drives Transcriptional Phenotypes of COPD and Relates to Immune and Metabolic Processes
por: Negewo, Netsanet A, et al.
Publicado: (2023)

Mechanism of azithromycin in airway diseases
por: Yang, Jie
Publicado: (2020)

A Sputum 6 Gene Expression Signature Predicts Inflammatory Phenotypes and Future Exacerbations of COPD
por: Baines, Katherine J, et al.
Publicado: (2020)

Use of azithromycin in the treatment of acute exacerbations of COPD
por: Milstone, Aaron P
Publicado: (2008)

A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro
por: Tang, Francesca S M, et al.
Publicado: (2016)

Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbations
por: O'Reilly, Philip J, et al.
Publicado: (2013)

The impact of azithromycin therapy on the airway microbiota in asthma
por: Slater, Mariel, et al.
Publicado: (2014)

Innate Immune Responses Are Increased in Chronic Obstructive Pulmonary Disease
por: Baines, Katherine Joanne, et al.
Publicado: (2011)

The differential effects of azithromycin on the airway epithelium in vitro and in vivo
por: Slater, Mariel, et al.
Publicado: (2016)

Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori
por: Ra, Seung Won, et al.
Publicado: (2017)

1297. Azithromycin vs Beta Lactams in Acute Exacerbations of COPD
por: Kale-Pradhan, Pramodini, et al.
Publicado: (2021)

Tracheostomy in children is associated with neutrophilic airway inflammation
por: Powell, Jason, et al.
Publicado: (2023)

Treatment burden, clinical outcomes, and comorbidities in COPD: an examination of the utility of medication regimen complexity index in COPD
por: Negewo, Netsanet A, et al.
Publicado: (2017)

An Alternate STAT6-Independent Pathway Promotes Eosinophil Influx into Blood during Allergic Airway Inflammation
por: Wang, Wan, et al.
Publicado: (2011)

Occupational exposures, smoking and airway inflammation in refractory asthma
por: Simpson, Jodie L, et al.
Publicado: (2014)

Systemic Inflammation in Older Adults With Asthma-COPD Overlap Syndrome
por: Fu, Juan-juan, et al.
Publicado: (2014)

The MIF Antagonist ISO-1 Attenuates Corticosteroid-Insensitive Inflammation and Airways Hyperresponsiveness in an Ozone-Induced Model of COPD
por: Russell, Kirsty E., et al.
Publicado: (2016)

Airway gene expression of IL-1 pathway mediators predicts exacerbation risk in obstructive airway disease
por: Baines, Katherine J, et al.
Publicado: (2017)

Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release
por: Bystrzycka, Weronika, et al.
Publicado: (2017)

Azithromycin Inhibits Mucus Hypersecretion from Airway Epithelial Cells
por: Shimizu, Takeshi, et al.
Publicado: (2012)

Azithromycin induces epidermal differentiation and multivesicular bodies in airway epithelia
por: Arason, Ari Jon, et al.
Publicado: (2019)

Long-term azithromycin therapy in patients with severe COPD and repeated exacerbations
por: Pomares, Xavier, et al.
Publicado: (2011)

Azithromycin Versus Beta-lactams in Hospitalized Patients with Acute Exacerbations of COPD
por: Baalbaki, Nour, et al.
Publicado: (2022)

An altered sputum macrophage transcriptome contributes to the neutrophilic asthma endotype
por: Fricker, Michael, et al.
Publicado: (2021)

Azithromycin for Malaria?
por: Rosenthal, Philip J.
Publicado: (2016)

Blood neutrophil counts are associated with exacerbation frequency and mortality in COPD
por: Lonergan, Mike, et al.
Publicado: (2020)

Blood cell for the differentiation of airway inflammatory phenotypes in COPD exacerbations
por: Gao, Jie, et al.
Publicado: (2020)

Sex differences in lymphoid follicles in COPD airways
por: Tam, Anthony, et al.
Publicado: (2020)

390 Evaluating Guideline-Recommended Antibiotic Prescribing Practices: Azithromycin for what?
por: Wright, Heather, et al.
Publicado: (2014)

Neutrophil-mediated delivery of the combination of colistin and azithromycin for the treatment of bacterial infection
por: Gao, Jiacong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8lb8vf5rhh2o5bju4qukgc15qa