Cargando…
A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells
The role of maternal and embryonic leucine zipper kinase (MELK) in cancer cell proliferation has been contentious, with recent studies arriving at disparate conclusions. We investigated the in vitro dependency of cancer cells on MELK under a range of assay conditions. Abrogation of MELK expression h...
Autores principales: | Wang, Yubao, Li, Ben B., Li, Jing, Roberts, Thomas M., Zhao, Jean J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215964/ https://www.ncbi.nlm.nih.gov/pubmed/30391850 http://dx.doi.org/10.1016/j.isci.2018.10.015 |
Ejemplares similares
-
MELK is not necessary for the proliferation of basal-like breast cancer cells
por: Huang, Hai-Tsang, et al.
Publicado: (2017) -
MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
por: Wang, Yubao, et al.
Publicado: (2014) -
Genome-wide effects of MELK-inhibitor in triple-negative breast cancer cells indicate context-dependent response with p53 as a key determinant
por: Simon, Marisa, et al.
Publicado: (2017) -
Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells
por: Wang, Yubao, et al.
Publicado: (2018) -
MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells
por: Joshi, Kaushal, et al.
Publicado: (2013)