Calcium signals between the ryanodine receptor- and mitochondria critically regulate the effects of arsenite on mitochondrial superoxide formation and on the ensuing survival vs apoptotic signaling

A low concentration of arsenite (6 h), selectively stimulating the intraluminal crosstalk between the inositol-1, 4, 5-triphosphate receptor and the ryanodine receptor (RyR), increased the mitochondrial transport of RyR-derived Ca(2+) through the mitochondrial Ca(2+) uniporter. This event was charac...

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Detalles Bibliográficos
Autores principales: Guidarelli, Andrea, Fiorani, Mara, Cerioni, Liana, Cantoni, Orazio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216081/
https://www.ncbi.nlm.nih.gov/pubmed/30388683
http://dx.doi.org/10.1016/j.redox.2018.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216081/
https://www.ncbi.nlm.nih.gov/pubmed/30388683
http://dx.doi.org/10.1016/j.redox.2018.10.015

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