Cargando…

Doublecortin-like kinase 1 compromises DNA repair and induces chromosomal instability

Doublecortin-like kinase 1 (DCLK1) is a serine/threonine-kinase with two doublecortin (DCX) domains. DCLK1 is associated with microtubules via DCX domains and regulates microtubule polymerization. DCLK1 is known to be expressed in cancer stem cells and provides cancer cells with tumor-initiating cap...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Yuxiong, Maruyama, Junichi, Kuwata, Keiko, Fukuda, Hiroyuki, Iwasa, Hiroaki, Arimoto-Matsuzaki, Kyoko, Sugimura, Haruhiko, Hata, Yutaka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216093/ https://www.ncbi.nlm.nih.gov/pubmed/30417131 http://dx.doi.org/10.1016/j.bbrep.2018.10.014

Ejemplares similares

CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells
por: Nagashima, Shunta, et al.
Publicado: (2021)

Protein kinase Cα activation switches YAP1 from TEAD‐mediated signaling to p73‐mediated signaling
por: Sinclear, Caleb Kwame, et al.
Publicado: (2022)

UNC119 is a binding partner of tumor suppressor Ras‐association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53
por: Iwasa, Hiroaki, et al.
Publicado: (2018)

The evolving doublecortin (DCX) superfamily
por: Reiner, Orly, et al.
Publicado: (2006)

Doublecortin Mutation in an Adolescent Male
por: Zare, Isabelle, et al.
Publicado: (2019)

Validation of chemical compound library screening for transcriptional co‐activator with PDZ‐binding motif inhibitors using GFP‐fused transcriptional co‐activator with PDZ‐binding motif
por: Nagashima, Shunta, et al.
Publicado: (2016)

Immunohistochemical study of doublecortin and nucleostemin in canine brain
por: De Nevi, E., et al.
Publicado: (2013)

Spatiotemporal Pattern of Doublecortin Expression in the Retina of the Sea Lamprey
por: Fernández-López, Blanca, et al.
Publicado: (2016)

Doublecortin-expressing cell types in temporal lobe epilepsy
por: Liu, Joan Y. W., et al.
Publicado: (2018)

Doublecortin in Oligodendrocyte Precursor Cells in the Adult Mouse Brain
por: Boulanger, Jenna J., et al.
Publicado: (2017)

Widespread Doublecortin Expression in the Cerebral Cortex of the Octodon degus
por: van Groen, Thomas, et al.
Publicado: (2021)

Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation
por: Shin, Euikyung, et al.
Publicado: (2013)

RASSF6; the Putative Tumor Suppressor of the RASSF Family
por: Iwasa, Hiroaki, et al.
Publicado: (2015)

Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells
por: Kodaka, Manami, et al.
Publicado: (2020)

Properties of Doublecortin Expressing Neurons in the Adult Mouse Dentate Gyrus
por: Spampanato, Jay, et al.
Publicado: (2012)

Evidence that Doublecortin Is Dispensable for the Development of Adult Born Neurons in Mice
por: Merz, Katharina, et al.
Publicado: (2013)

Doublecortin May Play a Role in Defining Chondrocyte Phenotype
por: Ge, Dongxia, et al.
Publicado: (2014)

Discovery of a selective inhibitor of Doublecortin Like Kinase 1
por: Ferguson, Fleur M., et al.
Publicado: (2020)

Autoregulatory control of microtubule binding in doublecortin-like kinase 1
por: Agulto, Regina L, et al.
Publicado: (2021)

Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites
por: Li, Peijun, et al.
Publicado: (2021)

Mechanisms of telomere loss and their consequences for chromosome instability
por: Muraki, Keiko, et al.
Publicado: (2012)

Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ
por: Terrados, Gloria, et al.
Publicado: (2009)

Cervical spine tuberculosis causing instability and neurological compromise
por: Sadek, Ahmed-Ramadan, et al.
Publicado: (2011)

Pseudo‐repeats in doublecortin make distinct mechanistic contributions to microtubule regulation
por: Manka, Szymon W, et al.
Publicado: (2020)

Doublecortin in the Fish Visual System, a Specific Protein of Maturing Neurons
por: DeOliveira-Mello, Laura, et al.
Publicado: (2022)

Human adipose-derived stromal/stem cells expressing doublecortin improve cartilage repair in rabbits and monkeys
por: Ge, Dongxia, et al.
Publicado: (2021)

TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
por: Arimoto-Matsuzaki, Kyoko, et al.
Publicado: (2016)

Correction: Characterization of a Natural Mutator Variant of Human DNA Polymerase λ which Promotes Chromosomal Instability by Compromising NHEJ
por: Terrados, Gloria, et al.
Publicado: (2009)

Doublecortin and CaM kinase-like-1 as an independent prognostic factor in patients with resected pancreatic carcinoma
por: Nishio, Kohei, et al.
Publicado: (2017)

Cyclooxygenase 2 in Gastric Carcinoma Is Expressed in Doublecortin- and CaM Kinase-Like-1-Positive Tuft Cells
por: Mutoh, Hiroyuki, et al.
Publicado: (2014)

Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung
por: Yamada, H Y, et al.
Publicado: (2016)

Increases in Doublecortin Immunoreactivity in the Dentate Gyrus following Extinction of Heroin-Seeking Behavior
por: Hicks, Megan P., et al.
Publicado: (2012)

Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts
por: Kunze, Albrecht, et al.
Publicado: (2015)

Doublecortin-like kinase 1 expression associates with breast cancer with neuroendocrine differentiation
por: Liu, Yu-Hong, et al.
Publicado: (2015)

Organelle and Cellular Abnormalities Associated with Hippocampal Heterotopia in Neonatal Doublecortin Knockout Mice
por: Khalaf-Nazzal, Reham, et al.
Publicado: (2013)

Dynamic microtubule association of Doublecortin X (DCX) is regulated by its C-terminus
por: Moslehi, Maryam, et al.
Publicado: (2017)

Doublecortin and Glypican-2 concentrations in the cerebrospinal fluid from infants are developmentally downregulated
por: Brégère, Catherine, et al.
Publicado: (2023)

Chromosome instability in neuroblastoma
por: Fusco, Pina, et al.
Publicado: (2018)

p53 Accumulation in Colorectal Cancer with Hepatic Metastasis
por: Maruyama, Keiji, et al.
Publicado: (1996)

Cascades of Genetic Instability Resulting from Compromised Break-Induced Replication
por: Vasan, Soumini, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_svinfp01tb2e9q0g7qft20lpom