Renal Function and Plasma Methotrexate Concentrations Predict Toxicities in Adults Receiving High-Dose Methotrexate

BACKGROUND: Methotrexate (MTX) is an effective drug for the treatment of adult malignancies, but toxicity remains a significant problem. Toxic reactions may occur when patients use high-dose MTX (HD-MTX), but the correlation between its toxicity and concentration in adults is controversial. The purp...

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Detalles Bibliográficos
Autores principales: Yang, Yunyun, Wang, Xuebin, Tian, Jing, Wang, Zhuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216510/
https://www.ncbi.nlm.nih.gov/pubmed/30369593
http://dx.doi.org/10.12659/MSM.912999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6216510/
https://www.ncbi.nlm.nih.gov/pubmed/30369593
http://dx.doi.org/10.12659/MSM.912999

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