Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1

Mutations affecting the spliceosomal protein U2AF1 are commonly found in myelodysplastic syndromes (MDS) and secondary acute myeloid leukemia (sAML). We have generated mice that carry Cre-dependent knock-in alleles of U2af1(S34F), the murine version of the most common mutant allele of U2AF1 encounte...

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Detalles Bibliográficos
Autores principales: Fei, Dennis Liang, Zhen, Tao, Durham, Benjamin, Ferrarone, John, Zhang, Tuo, Garrett, Lisa, Yoshimi, Akihide, Abdel-Wahab, Omar, Bradley, Robert K., Liu, Paul, Varmus, Harold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217397/
https://www.ncbi.nlm.nih.gov/pubmed/30322915
http://dx.doi.org/10.1073/pnas.1812669115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217397/
https://www.ncbi.nlm.nih.gov/pubmed/30322915
http://dx.doi.org/10.1073/pnas.1812669115

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