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Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein in the Presence of Dopamine
[Image: see text] The aggregates of α-synuclein bear a close connection with Parkinson’s disease, which is largely characterized by the loss of the dopaminergic neurons. Dopamine promotes the formation of undesirable sodium dodecyl sulfate (SDS)-resistant oligomers of α-synuclein. In this study, we...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217689/ https://www.ncbi.nlm.nih.gov/pubmed/30411062 http://dx.doi.org/10.1021/acsomega.8b00993 |
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author | Saha, Shivnetra Khan, Mohammad Ashhar Iqbal Mudhara, Deepak Deep, Shashank |
author_facet | Saha, Shivnetra Khan, Mohammad Ashhar Iqbal Mudhara, Deepak Deep, Shashank |
author_sort | Saha, Shivnetra |
collection | PubMed |
description | [Image: see text] The aggregates of α-synuclein bear a close connection with Parkinson’s disease, which is largely characterized by the loss of the dopaminergic neurons. Dopamine promotes the formation of undesirable sodium dodecyl sulfate (SDS)-resistant oligomers of α-synuclein. In this study, we have shown that the inhibition of fibrillation by an additive may not always be the ultimate deciding factor in the context of its potential as a successful additive. Copper promotes the fibrillation of α-synuclein in buffer alone but inhibits the formation of SDS-resistant oligomers in the presence of dopamine. Glycerol, on the other hand, increases the population of such dopamine-mediated SDS-resistant oligomers. We speculate such an effect to be a manifestation of the distinct oxidation pathway of dopamine in the presence of copper. |
format | Online Article Text |
id | pubmed-6217689 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-62176892018-11-06 Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein in the Presence of Dopamine Saha, Shivnetra Khan, Mohammad Ashhar Iqbal Mudhara, Deepak Deep, Shashank ACS Omega [Image: see text] The aggregates of α-synuclein bear a close connection with Parkinson’s disease, which is largely characterized by the loss of the dopaminergic neurons. Dopamine promotes the formation of undesirable sodium dodecyl sulfate (SDS)-resistant oligomers of α-synuclein. In this study, we have shown that the inhibition of fibrillation by an additive may not always be the ultimate deciding factor in the context of its potential as a successful additive. Copper promotes the fibrillation of α-synuclein in buffer alone but inhibits the formation of SDS-resistant oligomers in the presence of dopamine. Glycerol, on the other hand, increases the population of such dopamine-mediated SDS-resistant oligomers. We speculate such an effect to be a manifestation of the distinct oxidation pathway of dopamine in the presence of copper. American Chemical Society 2018-10-26 /pmc/articles/PMC6217689/ /pubmed/30411062 http://dx.doi.org/10.1021/acsomega.8b00993 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Saha, Shivnetra Khan, Mohammad Ashhar Iqbal Mudhara, Deepak Deep, Shashank Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein in the Presence of Dopamine |
title | Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein
in the Presence of Dopamine |
title_full | Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein
in the Presence of Dopamine |
title_fullStr | Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein
in the Presence of Dopamine |
title_full_unstemmed | Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein
in the Presence of Dopamine |
title_short | Tuning the Balance between Fibrillation and Oligomerization of α-Synuclein
in the Presence of Dopamine |
title_sort | tuning the balance between fibrillation and oligomerization of α-synuclein
in the presence of dopamine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217689/ https://www.ncbi.nlm.nih.gov/pubmed/30411062 http://dx.doi.org/10.1021/acsomega.8b00993 |
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