Mutant TRP53 exerts a target gene-selective dominant-negative effect to drive tumor development

Mutations in Trp53, prevalent in human cancer, are reported to drive tumorigenesis through dominant-negative effects (DNEs) over wild-type TRP53 function as well as neomorphic gain-of-function (GOF) activity. We show that five TRP53 mutants do not accelerate lymphomagenesis on a TRP53-deficient back...

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Detalles Bibliográficos
Autores principales: Aubrey, Brandon J., Janic, Ana, Chen, Yunshun, Chang, Catherine, Lieschke, Elizabeth C., Diepstraten, Sarah T., Kueh, Andrew J., Bernardini, Jonathan P., Dewson, Grant, O'Reilly, Lorraine A., Whitehead, Lachlan, Voss, Anne K., Smyth, Gordon K., Strasser, Andreas, Kelly, Gemma L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217734/
https://www.ncbi.nlm.nih.gov/pubmed/30366906
http://dx.doi.org/10.1101/gad.314286.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217734/
https://www.ncbi.nlm.nih.gov/pubmed/30366906
http://dx.doi.org/10.1101/gad.314286.118

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