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Leveraging DNA-Methylation Quantitative-Trait Loci to Characterize the Relationship between Methylomic Variation, Gene Expression, and Complex Traits

Characterizing the complex relationship between genetic, epigenetic, and transcriptomic variation has the potential to increase understanding about the mechanisms underpinning health and disease phenotypes. We undertook a comprehensive analysis of common genetic variation on DNA methylation (DNAm) b...

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Detalles Bibliográficos
Autores principales: Hannon, Eilis, Gorrie-Stone, Tyler J., Smart, Melissa C., Burrage, Joe, Hughes, Amanda, Bao, Yanchun, Kumari, Meena, Schalkwyk, Leonard C., Mill, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217758/
https://www.ncbi.nlm.nih.gov/pubmed/30401456
http://dx.doi.org/10.1016/j.ajhg.2018.09.007