Cargando…

TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity

BACKGROUND: Obesity exerts negative effects on brain health, including decreased neurogenesis, impaired learning and memory, and increased risk for Alzheimer’s disease and related dementias. Because obesity promotes glial activation, chronic neuroinflammation, and neural injury, microglia are implic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moser, V. Alexandra, Uchoa, Mariana F., Pike, Christian J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217784/ https://www.ncbi.nlm.nih.gov/pubmed/30396359 http://dx.doi.org/10.1186/s12974-018-1340-0

Ejemplares similares

TAK242 suppresses the TLR4 signaling pathway and ameliorates DCD liver IRI in rats
por: Zhong, Xiang, et al.
Publicado: (2019)

Inhibition of intimal hyperplasia in murine aortic allografts by administration of a small-molecule TLR4 inhibitor TAK-242
por: Wu, Chuangyan, et al.
Publicado: (2017)

Investigation of toll-like receptor (TLR) 4 inhibitor TAK-242 as a new potential anti-rheumatoid arthritis drug
por: Samarpita, Snigdha, et al.
Publicado: (2020)

TAK-242 ameliorates epileptic symptoms in mice by inhibiting the TLR4/NF-κB signaling pathway
por: Dong, Jibo, et al.
Publicado: (2022)

Sulfonamide Prodrugs with a Two-Stage Release Mechanism for the Efficient Delivery of the TLR4 Antagonist TAK-242
por: Kostyo, Jessica H., et al.
Publicado: (2022)

Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model
por: Fellner, Avi, et al.
Publicado: (2017)

TAK-242 Ameliorates Hepatic Fibrosis by Regulating the Liver-Gut Axis
por: Liu, Sujie, et al.
Publicado: (2022)

Selective inhibition of Toll-like receptor 4 signaling by the small molecule TAK-242
por: Kawamoto, T, et al.
Publicado: (2006)

Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress
por: Gárate, Iciar, et al.
Publicado: (2014)

The Toll-like receptor 4 antagonist TAK-242 protects against chronic pancreatitis in rats
por: Pan, Long-Fei, et al.
Publicado: (2017)

TAK-242 ameliorates contact dermatitis exacerbated by IL-36 receptor antagonist deficiency
por: Fukushima, Hidehiko, et al.
Publicado: (2020)

TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice
por: Ono, Yuko, et al.
Publicado: (2020)

Prenatal exposure to TAK242 affects the childhood autism in offspring in animal models of autism spectrum disorder
por: Xu, Xiaoyan, et al.
Publicado: (2017)

TAK-242, a Toll-Like Receptor 4 Antagonist, Protects against Aldosterone-Induced Cardiac and Renal Injury
por: Zhang, Yide, et al.
Publicado: (2015)

TAK-242, an antagonist for Toll-like receptor 4, protects against acute cerebral ischemia/reperfusion injury in mice
por: Hua, Fang, et al.
Publicado: (2015)

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis
por: Bhattacharyya, Swati, et al.
Publicado: (2018)

TAK-242, a toll-like receptor 4 antagonist, against brain injury by alleviates autophagy and inflammation in rats
por: Feng, Yan, et al.
Publicado: (2023)

TAK-242 ameliorates DSS-induced colitis by regulating the gut microbiota and the JAK2/STAT3 signaling pathway
por: Wang, Jiajia, et al.
Publicado: (2020)

TAK-242, a novel Toll-like receptor 4 signal transduction inhibitor, protects mice in Escherichia coli-induced and lipoteichoic acid-induced lethality models
por: Ii, M, et al.
Publicado: (2006)

TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipidinduced inflammation and insulin resistance in muscle cells
por: Hussey, Sophie E., et al.
Publicado: (2012)

TAK-242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF-κB signaling pathway in a neonatal hypoxic-ischemic encephalopathy rat model
por: Jiang, Lijun, et al.
Publicado: (2020)

TAK-242 protects against oxygen-glucose deprivation and reoxygenation-induced injury in brain microvascular endothelial cells and alters the expression pattern of lncRNAs
por: Kong, Li-Yun, et al.
Publicado: (2023)

Targeting Toll-like receptor 4 with CLI-095 (TAK-242) enhances the antimetastatic effect of the estrogen receptor antagonist fulvestrant on non-small cell lung cancer
por: Fan, S., et al.
Publicado: (2020)

Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function
por: Jayaraman, Anusha, et al.
Publicado: (2014)

sNASP Mutation Aggravates to the TLR4-Mediated Inflammation in SLE by TAK1 Pathway
por: Bao, Yatao, et al.
Publicado: (2023)

Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice
por: Moser, V. Alexandra, et al.
Publicado: (2017)

Health Tract, No. 242: Emergencies
Publicado: (1866)

TAK1 protein kinase activity is required for TLR signalling and cytokine production in myeloid cells
por: Rodrigues, Melissa, et al.
Publicado: (2022)

TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma
por: Campolo, Michela, et al.
Publicado: (2020)

TAK1 inhibition attenuates both inflammation and fibrosis in experimental pneumoconiosis
por: Li, Jie, et al.
Publicado: (2017)

ODP242 Safety of SGLT2-Inhibitors in Patients with Multiple Myeloma and Diabetes
por: Shyu, Margaret, et al.
Publicado: (2022)

DNA2.4.2 - Exploitation and Sustainability Plan
por: Members of EMI collaboration
Publicado: (Apri)

TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling
por: Yang, Wanlei, et al.
Publicado: (2021)

SAT-242 Isolated Adrenocorticotropic Hormone Deficiency Secondary to the PD-1 Inhibitor Pembrolizumab
por: Mathew, Justin, et al.
Publicado: (2020)

Distinct roles of TRAF6 and TAK1 in the regulation of adipocyte survival, thermogenesis program, and high-fat diet-induced obesity
por: Gallot, Yann S., et al.
Publicado: (2017)

TLR3/TAK1 signalling regulates rhinovirus-induced interleukin-33 in bronchial smooth muscle cells
por: Ramu, Sangeetha, et al.
Publicado: (2020)

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity
por: Ji, Yewei, et al.
Publicado: (2019)

IAU Symposium 242: Astrophysical masers and their environments
Publicado: (2007)

Analysis of 242 Cases of Sprue in Indian Troops
por: Karamchandani, P. V., et al.
Publicado: (1946)

242 Characterization of Maternal Stress During Pregnancy
por: Dhaliwal, Satvinder K., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_rgar5b2brjjgbt6gv489e21fvr