Elucidating the multi-targeted anti-amyloid activity and enhanced islet amyloid polypeptide binding of β-wrapins

β-wrapins are engineered binding proteins stabilizing the β-hairpin conformations of amyloidogenic proteins islet amyloid polypeptide (IAPP), amyloid-β, and α-synuclein, thus inhibiting their amyloid propensity. Here, we use computational and experimental methods to investigate the molecular recogni...

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Detalles Bibliográficos
Autores principales: Orr, Asuka A., Shaykhalishahi, Hamed, Mirecka, Ewa A., Jonnalagadda, Sai Vamshi R., Hoyer, Wolfgang, Tamamis, Phanourios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217933/
https://www.ncbi.nlm.nih.gov/pubmed/30405276
http://dx.doi.org/10.1016/j.compchemeng.2018.02.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217933/
https://www.ncbi.nlm.nih.gov/pubmed/30405276
http://dx.doi.org/10.1016/j.compchemeng.2018.02.013

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