Deregulation of the imprinted DLK1-DIO3 locus ncRNAs is associated with replicative senescence of human adipose-derived stem cells

BACKGROUND: Human adult adipose-derived stem cells (hADSCs) have become the most promising cell source for regenerative medicine. However the prolonged ex vivo expansion periods required to obtain the necessary therapeutic dose promotes progressive senescence, with the concomitant reduction of their...

Descripción completa

Detalles Bibliográficos
Autores principales: García-López, Silvia, Albo-Castellanos, Carmen, Urdinguio, Rocio G., Cañón, Susana, Sánchez-Cabo, Fátima, Martínez-Serrano, Alberto, Fraga, Mario F., Bernad, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218046/
https://www.ncbi.nlm.nih.gov/pubmed/30395586
http://dx.doi.org/10.1371/journal.pone.0206534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218046/
https://www.ncbi.nlm.nih.gov/pubmed/30395586
http://dx.doi.org/10.1371/journal.pone.0206534

Ejemplares similares