Mutant myocilin impacts sarcomere ultrastructure in mouse gastrocnemius muscle

Myocilin (MYOC) is the gene with mutations most common in glaucoma. In the eye, MYOC is in trabecular meshwork, ciliary body, and retina. Other tissues with high MYOC transcript levels are skeletal muscle and heart. To date, the function of wild-type MYOC remains unknown and how mutant MYOC causes h...

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Detalles Bibliográficos
Autores principales: Lynch, Jeffrey M., Dolman, Andrew J., Guo, Chenying, Dolan, Katie, Xiang, Chuanxi, Reda, Samir, Li, Bing, Prasanna, Ganesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218065/
https://www.ncbi.nlm.nih.gov/pubmed/30395621
http://dx.doi.org/10.1371/journal.pone.0206801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218065/
https://www.ncbi.nlm.nih.gov/pubmed/30395621
http://dx.doi.org/10.1371/journal.pone.0206801

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