Microtubule Imaging Reveals Cytoskeletal Deficit Predisposing the Retinal Ganglion Cell Axons to Atrophy in DBA/2J

PURPOSE: Glaucoma is characterized by progressive loss of the retinal ganglion cells (RGCs) and their axons. Here we test an outstanding notion that microtubules (MTs) within RGC axons degrade before the loss of morphology (“MT hypothesis”). METHODS: The integrity of axonal MTs was interrogated by i...

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Detalles Bibliográficos
Autores principales: Sharoukhov, Denis, Bucinca-Cupallari, Festa, Lim, Hyungsik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218151/
https://www.ncbi.nlm.nih.gov/pubmed/30383181
http://dx.doi.org/10.1167/iovs.18-24150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218151/
https://www.ncbi.nlm.nih.gov/pubmed/30383181
http://dx.doi.org/10.1167/iovs.18-24150

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