LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L‐plastin

Mice with disruption of Lrrk1 and patients with nonfunctional mutant Lrrk1 exhibit severe osteopetrosis phenotypes because of osteoclast cytoskeletal dysfunction. To understand how Lrrk1 regulates osteoclast function by modulating cytoskeleton rearrangement, we examined the proteins that are differe...

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Detalles Bibliográficos
Autores principales: Si, Mingjue, Goodluck, Helen, Zeng, Canjun, Pan, Songqin, Todd, Elizabeth M., Morley, Sharon Celeste, Qin, Xuezhong, Mohan, Subburaman, Xing, Weirong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218268/
https://www.ncbi.nlm.nih.gov/pubmed/30136304
http://dx.doi.org/10.1002/jcb.27377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218268/
https://www.ncbi.nlm.nih.gov/pubmed/30136304
http://dx.doi.org/10.1002/jcb.27377

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