Does Substrate Positioning Affect the Selectivity and Reactivity in the Hectochlorin Biosynthesis Halogenase?

In this work we present the first computational study on the hectochlorin biosynthesis enzyme HctB, which is a unique three-domain halogenase that activates non-amino acid moieties tethered to an acyl-carrier, and as such may have biotechnological relevance beyond other halogenases. We use a combina...

Descripción completa

Detalles Bibliográficos
Autores principales: Timmins, Amy, Fowler, Nicholas J., Warwicker, Jim, Straganz, Grit D., de Visser, Sam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218459/
https://www.ncbi.nlm.nih.gov/pubmed/30425979
http://dx.doi.org/10.3389/fchem.2018.00513

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218459/
https://www.ncbi.nlm.nih.gov/pubmed/30425979
http://dx.doi.org/10.3389/fchem.2018.00513

Ejemplares similares