Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma

Metastatic melanoma remains a life-threatening disease because most tumors develop resistance to targeted kinase inhibitors thereby regaining tumorigenic capacity. We show the 2nd generation hexavalent TRAIL receptor-targeted agonist IZI1551 to induce pronounced apoptotic cell death in mutBRAF melan...

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Detalles Bibliográficos
Autores principales: Del Mistro, Greta, Lucarelli, Philippe, Müller, Ines, De Landtsheer, Sébastien, Zinoveva, Anna, Hutt, Meike, Siegemund, Martin, Kontermann, Roland E., Beissert, Stefan, Sauter, Thomas, Kulms, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218484/
https://www.ncbi.nlm.nih.gov/pubmed/30416750
http://dx.doi.org/10.1038/s41540-018-0075-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218484/
https://www.ncbi.nlm.nih.gov/pubmed/30416750
http://dx.doi.org/10.1038/s41540-018-0075-y

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