Cargando…
Proteomic approach for understanding milder neurotoxicity of Carfilzomib against Bortezomib
The proteasomal system is responsible for the turnover of damaged proteins. Because of its important functions in oncogenesis, inhibiting the proteasomal system is a promising therapeutic approach for cancer treatment. Bortezomib (BTZ) is the first proteasome inhibitor approved by FDA for clinical a...
Autores principales: | Karademir, Betul, Sari, Gulce, Jannuzzi, Ayse Tarbin, Musunuri, Sravani, Wicher, Grzegorz, Grune, Tilman, Mi, Jia, Hacioglu-Bay, Husniye, Forsberg-Nilsson, Karin, Bergquist, Jonas, Jung, Tobias |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218500/ https://www.ncbi.nlm.nih.gov/pubmed/30397214 http://dx.doi.org/10.1038/s41598-018-34507-3 |
Ejemplares similares
-
Higher proteotoxic stress rather than mitochondrial damage is involved in higher neurotoxicity of bortezomib compared to carfilzomib
por: Jannuzzi, Ayse Tarbin, et al.
Publicado: (2020) -
Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events
por: Tsakiri, Eleni N., et al.
Publicado: (2017) -
Tubulin binding potentially clears up Bortezomib and Carfilzomib differential neurotoxic effect
por: Malacrida, A., et al.
Publicado: (2021) -
Nelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance
por: Kraus, M, et al.
Publicado: (2013) -
Exploring the Anticancer Effects of Brominated Plastoquinone Analogs with Promising Cytotoxic Activity in MCF-7 Breast Cancer Cells via Cell Cycle Arrest and Oxidative Stress Induction
por: Jannuzzi, Ayse Tarbin, et al.
Publicado: (2022)