Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats

Ribosomal DNA (rDNA) repeat instability and protein aggregation are thought to be two major and independent drivers of cellular aging. Pbp1, the yeast ortholog of human ATXN2, maintains rDNA repeat stability and lifespan via suppression of RNA–DNA hybrids. ATXN2 polyglutamine expansion drives neurod...

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Detalles Bibliográficos
Autores principales: Ostrowski, Lauren A., Hall, Amanda C., Szafranski, Kirk J., Oshidari, Roxanne, Abraham, Karan J., Chan, Janet N. Y., Krustev, Christian, Zhang, Kevin, Wang, Ashley, Liu, Yupeng, Guo, Ru, Mekhail, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218562/
https://www.ncbi.nlm.nih.gov/pubmed/30417124
http://dx.doi.org/10.1038/s42003-018-0187-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218562/
https://www.ncbi.nlm.nih.gov/pubmed/30417124
http://dx.doi.org/10.1038/s42003-018-0187-3

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