Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress

The DNA helicase FANCJ is mutated in hereditary breast and ovarian cancer and Fanconi anemia (FA). Nevertheless, how loss of FANCJ translates to disease pathogenesis remains unclear. We addressed this question by analyzing proteins associated with replication forks in cells with or without FANCJ. We...

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Detalles Bibliográficos
Autores principales: Peng, Min, Cong, Ke, Panzarino, Nicholas J., Nayak, Sumeet, Calvo, Jennifer, Deng, Bin, Zhu, Lihua Julie, Morocz, Monika, Hegedus, Lili, Haracska, Lajos, Cantor, Sharon B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218949/
https://www.ncbi.nlm.nih.gov/pubmed/30232006
http://dx.doi.org/10.1016/j.celrep.2018.08.065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218949/
https://www.ncbi.nlm.nih.gov/pubmed/30232006
http://dx.doi.org/10.1016/j.celrep.2018.08.065

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