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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress
The DNA helicase FANCJ is mutated in hereditary breast and ovarian cancer and Fanconi anemia (FA). Nevertheless, how loss of FANCJ translates to disease pathogenesis remains unclear. We addressed this question by analyzing proteins associated with replication forks in cells with or without FANCJ. We...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218949/ https://www.ncbi.nlm.nih.gov/pubmed/30232006 http://dx.doi.org/10.1016/j.celrep.2018.08.065 |