VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In...

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Detalles Bibliográficos
Autores principales: Ji, Ning, Yang, Yuqi, Cai, Chao-Yun, Lei, Zi-Ning, Wang, Jing-Quan, Gupta, Pranav, Teng, Qiu-Xu, Chen, Zhe-Sheng, Kong, Dexin, Yang, Dong-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218957/
https://www.ncbi.nlm.nih.gov/pubmed/30425643
http://dx.doi.org/10.3389/fphar.2018.01236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218957/
https://www.ncbi.nlm.nih.gov/pubmed/30425643
http://dx.doi.org/10.3389/fphar.2018.01236

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