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PA28αβ overexpression enhances learning and memory of female mice without inducing 20S proteasome activity

BACKGROUND: The proteasome system plays an important role in synaptic plasticity. Induction and maintenance of long term potentiation is directly dependent on selective targeting of proteins for proteasomal degradation. The 20S proteasome activator PA28αβ activates hydrolysis of small nonubiquitinat...

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Detalles Bibliográficos
Autores principales: Adelöf, Julia, Andersson, My, Porritt, Michelle, Petersen, Anne, Zetterberg, Madeleine, Wiseman, John, Hernebring, Malin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218978/
https://www.ncbi.nlm.nih.gov/pubmed/30400847
http://dx.doi.org/10.1186/s12868-018-0468-2