A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes

BACKGROUND: Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies also suggest that CDG mutations contribute to cancer-associated epigenomic and transcriptomic alterations across many cancer types. Here we aim to improve our...

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Detalles Bibliográficos
Autores principales: Youn, Ahrim, Kim, Kyung In, Rabadan, Raul, Tycko, Benjamin, Shen, Yufeng, Wang, Shuang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218985/
https://www.ncbi.nlm.nih.gov/pubmed/30400878
http://dx.doi.org/10.1186/s12920-018-0425-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218985/
https://www.ncbi.nlm.nih.gov/pubmed/30400878
http://dx.doi.org/10.1186/s12920-018-0425-z

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