CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis

A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.

Detalles Bibliográficos
Autores principales: Guo, Xiang, Dean, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219166/
https://www.ncbi.nlm.nih.gov/pubmed/30400943
http://dx.doi.org/10.1186/s13059-018-1569-z
Descripción
Sumario:A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.

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