CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis

A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.

Detalles Bibliográficos
Autores principales: Guo, Xiang, Dean, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219166/
https://www.ncbi.nlm.nih.gov/pubmed/30400943
http://dx.doi.org/10.1186/s13059-018-1569-z
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author Guo, Xiang
Dean, Ann
author_facet Guo, Xiang
Dean, Ann
author_sort Guo, Xiang
collection PubMed
description A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer.
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spelling pubmed-62191662018-11-16 CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis Guo, Xiang Dean, Ann Genome Biol Research Highlight A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer. BioMed Central 2018-11-06 /pmc/articles/PMC6219166/ /pubmed/30400943 http://dx.doi.org/10.1186/s13059-018-1569-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Guo, Xiang
Dean, Ann
CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis
title CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis
title_full CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis
title_fullStr CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis
title_full_unstemmed CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis
title_short CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis
title_sort crispr/cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219166/
https://www.ncbi.nlm.nih.gov/pubmed/30400943
http://dx.doi.org/10.1186/s13059-018-1569-z
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AT deanann crisprcas9offersanewtoolforstudyingtheroleofchromatinarchitectureindiseasepathogenesis

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