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Nuclear transport inhibition in acute myeloid leukemia: recent advances and future perspectives

Selective inhibitors of nuclear export (SINE) are emerging as a potentially efficacious therapeutic strategy for overcoming resistance to conventional chemotherapy for acute myeloid leukemia. SINE specifically block the protein Exportin 1, also known as chromosomal region maintenance 1, leading to n...

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Detalles Bibliográficos
Autores principales: Talati, Chetasi, Sweet, Kendra L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219429/
https://www.ncbi.nlm.nih.gov/pubmed/30405902
http://dx.doi.org/10.2217/ijh-2018-0001