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DNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans

DNA-protein crosslinks (DPCs) are a specific type of DNA lesion consisting of a protein covalently and irreversibly bound to DNA, which arise after exposure to physical and chemical crosslinking agents. DPCs can be bulky and thereby pose a barrier to DNA replication and transcription. The persistenc...

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Detalles Bibliográficos
Autores principales:	Fielden, John, Ruggiano, Annamaria, Popović, Marta, Ramadan, Kristijan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219452/ https://www.ncbi.nlm.nih.gov/pubmed/30170832 http://dx.doi.org/10.1016/j.dnarep.2018.08.025

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