Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs

Classic endocytosis destinations include the recycling endosome returning to the plasma membrane or the late endosome (LE) merging with lysosomes for cargo degradation. However, the anti-angiogenic proteins angiostatin and isthmin, are endocytosed and trafficked to mitochondria (Mito) to execute apo...

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Detalles Bibliográficos
Autores principales: Chen, Mo, Qiu, Tao, Wu, Jiajie, Yang, Yang, Wright, Graham D., Wu, Min, Ge, Ruowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219483/
https://www.ncbi.nlm.nih.gov/pubmed/29523874
http://dx.doi.org/10.1038/s41418-018-0092-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219483/
https://www.ncbi.nlm.nih.gov/pubmed/29523874
http://dx.doi.org/10.1038/s41418-018-0092-9

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