Aggregated SOD1 causes selective death of cultured human motor neurons

Most human neurodegenerative diseases share a phenotype of neuronal protein aggregation. In Amyotrophic Lateral Sclerosis (ALS), the abundant protein superoxide dismutase (SOD1) or the TAR-DNA binding protein TDP-43 can aggregate in motor neurons. Recently, numerous studies have highlighted the abil...

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Detalles Bibliográficos
Autores principales: Benkler, Chen, O’Neil, Alison L., Slepian, Susannah, Qian, Fang, Weinreb, Paul H., Rubin, Lee L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219543/
https://www.ncbi.nlm.nih.gov/pubmed/30401824
http://dx.doi.org/10.1038/s41598-018-34759-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219543/
https://www.ncbi.nlm.nih.gov/pubmed/30401824
http://dx.doi.org/10.1038/s41598-018-34759-z

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