An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1

Bestrophin proteins are calcium (Ca(2+))-activated chloride channels. Mutations in bestrophin 1 (BEST1) cause macular degenerative disorders. Whole-cell recordings show that ionic currents through BEST1 run down over time, but it is unclear whether this behavior is intrinsic to the channel or the re...

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Detalles Bibliográficos
Autores principales: Vaisey, George, Long, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219684/
https://www.ncbi.nlm.nih.gov/pubmed/30237227
http://dx.doi.org/10.1085/jgp.201812190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219684/
https://www.ncbi.nlm.nih.gov/pubmed/30237227
http://dx.doi.org/10.1085/jgp.201812190

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