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An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1
Bestrophin proteins are calcium (Ca(2+))-activated chloride channels. Mutations in bestrophin 1 (BEST1) cause macular degenerative disorders. Whole-cell recordings show that ionic currents through BEST1 run down over time, but it is unclear whether this behavior is intrinsic to the channel or the re...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219684/ https://www.ncbi.nlm.nih.gov/pubmed/30237227 http://dx.doi.org/10.1085/jgp.201812190 |