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Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation
Monocytes are crucial immune cells involved in regulation of inflammation either directly or via differentiation into macrophages in tissues. However, many aspects of how their function is controlled in health and disease are not understood. Here we show that human blood monocytes activate high leve...
Autores principales: | Kelly, Aoife, Gunaltay, Sezin, McEntee, Craig P., Shuttleworth, Elinor E., Smedley, Catherine, Houston, Stephanie A., Fenton, Thomas M., Levison, Scott, Mann, Elizabeth R., Travis, Mark A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219736/ https://www.ncbi.nlm.nih.gov/pubmed/30355614 http://dx.doi.org/10.1084/jem.20171491 |
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