Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5

MHCII in antigen-presenting cells (APCs) is a key regulator of adaptive immune responses. Expression of MHCII genes is controlled by the transcription coactivator CIITA, itself regulated through cell type–specific promoters. Here we show that the transcription factor NFAT5 is needed for expression o...

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Detalles Bibliográficos
Autores principales: Buxadé, Maria, Huerga Encabo, Hector, Riera-Borrull, Marta, Quintana-Gallardo, Lucía, López-Cotarelo, Pilar, Tellechea, Mónica, Martínez-Martínez, Sara, Redondo, Juan Miguel, Martín-Caballero, Juan, Flores, Juana María, Bosch, Elena, Rodríguez-Fernández, José Luis, Aramburu, Jose, López-Rodríguez, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219740/
https://www.ncbi.nlm.nih.gov/pubmed/30327417
http://dx.doi.org/10.1084/jem.20180314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219740/
https://www.ncbi.nlm.nih.gov/pubmed/30327417
http://dx.doi.org/10.1084/jem.20180314

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