KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer

PTEN deficiency in breast cancer leads to resistance to PI3K–AKT inhibitor treatment despite aberrant activation of this signaling pathway. Here, we report that genetic depletion or small molecule inhibition of KDM4B histone demethylase activates the unfolded protein response (UPR) pathway and resul...

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Detalles Bibliográficos
Autores principales: Wang, Wenyu, Oguz, Gokce, Lee, Puay Leng, Bao, Yi, Wang, Panpan, Terp, Mikkel Green, Ditzel, Henrik J., Yu, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219741/
https://www.ncbi.nlm.nih.gov/pubmed/30266800
http://dx.doi.org/10.1084/jem.20180439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219741/
https://www.ncbi.nlm.nih.gov/pubmed/30266800
http://dx.doi.org/10.1084/jem.20180439

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