Cargando…

KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer

PTEN deficiency in breast cancer leads to resistance to PI3K–AKT inhibitor treatment despite aberrant activation of this signaling pathway. Here, we report that genetic depletion or small molecule inhibition of KDM4B histone demethylase activates the unfolded protein response (UPR) pathway and resul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Wenyu, Oguz, Gokce, Lee, Puay Leng, Bao, Yi, Wang, Panpan, Terp, Mikkel Green, Ditzel, Henrik J., Yu, Qiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219741/ https://www.ncbi.nlm.nih.gov/pubmed/30266800 http://dx.doi.org/10.1084/jem.20180439

Ejemplares similares

The role of GAGE cancer/testis antigen in metastasis: the jury is still out
por: Gjerstorff, Morten Frier, et al.
Publicado: (2016)

EZH2-mediated PP2A inactivation confers resistance to HER2-targeted breast cancer therapy
por: Bao, Yi, et al.
Publicado: (2020)

Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy
por: Ma, Shijun, et al.
Publicado: (2022)

SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
por: Romero, Octavio A., et al.
Publicado: (2021)

Human cancer evolution in the context of a human immune system in mice
por: Gammelgaard, Odd L., et al.
Publicado: (2018)

IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer
por: Ong, Li-Teng, et al.
Publicado: (2022)

Replication and ribosomal stress induced by targeting pyrimidine synthesis and cellular checkpoints suppress p53-deficient tumors
por: Hubackova, Sona, et al.
Publicado: (2020)

HMGA2 Supports Cancer Hallmarks in Triple-Negative Breast Cancer
por: Mansoori, Behzad, et al.
Publicado: (2021)

Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes
por: Terp, Mikkel G., et al.
Publicado: (2021)

ZBED1 Regulates Genes Important for Multiple Biological Processes of the Placenta
por: Johansen, Simone, et al.
Publicado: (2022)

Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer
por: Tang, Yew Chung, et al.
Publicado: (2018)

PDX Models: A Versatile Tool for Studying the Role of Myeloid-Derived Suppressor Cells in Breast Cancer
por: Gjerstorff, Morten F., et al.
Publicado: (2022)

SSX addiction in melanoma propagates tumor growth and metastasis
por: Traynor, Sofie, et al.
Publicado: (2022)

Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins
por: Traynor, Sofie, et al.
Publicado: (2019)

The PTEN Conundrum: How to Target PTEN-Deficient Prostate Cancer
por: Turnham, Daniel J., et al.
Publicado: (2020)

Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance
por: Li, Fei, et al.
Publicado: (2023)

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
por: Wang, Wenyu, et al.
Publicado: (2021)

Triple combination targeting PI3K, ER, and CDK4/6 inhibits growth of ER‐positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor
por: Karimi, Leena, et al.
Publicado: (2023)

KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations
por: Wang, Kaiqing, et al.
Publicado: (2023)

Comparative Analysis of Stk11/Lkb1 versus Pten Deficiency in Lung Adenocarcinoma Induced by CRISPR/Cas9
por: Berthelsen, Martin F., et al.
Publicado: (2021)

Lifestyle diseases and cardiovascular risk factors are interrelated to deficiencies of major substrates in ATP synthesis
por: Ditzel, Jørn, et al.
Publicado: (2010)

miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations
por: Thomsen, Karina G., et al.
Publicado: (2015)

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2
por: Hubackova, Sona, et al.
Publicado: (2018)

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo
por: Botkjaer, Kenneth A., et al.
Publicado: (2016)

The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors
por: Jakobsen, Mie K., et al.
Publicado: (2021)

DDX56 modulates post-transcriptional Wnt signaling through miRNAs and is associated with early recurrence in squamous cell lung carcinoma
por: Wu, Qingqing, et al.
Publicado: (2021)

Combined FGFR and Akt pathway inhibition abrogates growth of FGFR1 overexpressing EGFR-TKI-resistant NSCLC cells
por: Terp, Mikkel G., et al.
Publicado: (2021)

NLK Is a Novel Therapeutic Target for PTEN Deficient Tumour Cells
por: Mendes-Pereira, Ana M., et al.
Publicado: (2012)

Systemic Deficiency of PTEN Accelerates Breast Cancer Growth and Metastasis
por: Chen, Jing, et al.
Publicado: (2022)

The EP300, KDM5A, KDM6A and KDM6B Chromatin Regulators Cooperate with KLF4 in the Transcriptional Activation of POU5F1
por: Wang, Wan-Ping, et al.
Publicado: (2012)

PTEN deficiency: a role in mammary carcinogenesis
por: Petrocelli, Teresa, et al.
Publicado: (2001)

KDM6B Variants May Contribute to the Pathophysiology of Human Cerebral Folate Deficiency
por: Han, Xiao, et al.
Publicado: (2022)

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
por: Wee, Zhen Ning, et al.
Publicado: (2015)

KDM5D Histone Demethylase Identifies Platinum-Tolerant Head and Neck Cancer Cells Vulnerable to Mitotic Catastrophe
por: Chen, Tsung-Ming, et al.
Publicado: (2023)

Correction: Corrigendum: IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel
por: Wee, Zhen Ning, et al.
Publicado: (2015)

Regulation of Epigenetic Modifiers, Including KDM6B, by Interferon-γ and Interleukin-4 in Human Macrophages
por: Yıldırım-Buharalıoğlu, Gökçe, et al.
Publicado: (2017)

Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A
por: Walters, Zoë S., et al.
Publicado: (2021)

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence
por: Brückmann, Nadine H., et al.
Publicado: (2019)

Co-targeting CDK2 and CDK4/6 overcomes resistance to aromatase and CDK4/6 inhibitors in ER+ breast cancer
por: Al-Qasem, Abeer J., et al.
Publicado: (2022)

The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway
por: Sidak-Loftis, Lindsay C., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_klmn5qvprvmdvkdo92l1iuljvt