Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models

Mutations in superoxide dismutase 1 (SOD1) associated with familial amyotrophic lateral sclerosis (fALS) induce the protein to misfold and aggregate. Missense mutations at more than 80 different amino acid positions have been associated with disease. How these mutations heighten the propensity of SO...

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Detalles Bibliográficos
Autores principales: Crosby, Keith, Crown, Anthony M., Roberts, Brittany L., Brown, Hilda, Ayers, Jacob I., Borchelt, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219784/
https://www.ncbi.nlm.nih.gov/pubmed/30399166
http://dx.doi.org/10.1371/journal.pone.0206751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219784/
https://www.ncbi.nlm.nih.gov/pubmed/30399166
http://dx.doi.org/10.1371/journal.pone.0206751

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