De novo design of a non-local β-sheet protein with high stability and accuracy

β-sheet proteins carry out critical functions in biology, and hence are attractive scaffolds for computational protein design. Despite this potential, de novo design of all β-sheet proteins from first principles lags far behind the design of all-α or mixed αβ domains due to their non-local nature an...

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Detalles Bibliográficos
Autores principales: Marcos, Enrique, Chidyausiku, Tamuka M., McShan, Andrew C., Evangelidis, Thomas, Nerli, Santrupti, Carter, Lauren, Nivón, Lucas G., Davis, Audrey, Oberdorfer, Gustav, Tripsianes, Konstantinos, Sgourakis, Nikolaos G., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219906/
https://www.ncbi.nlm.nih.gov/pubmed/30374087
http://dx.doi.org/10.1038/s41594-018-0141-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219906/
https://www.ncbi.nlm.nih.gov/pubmed/30374087
http://dx.doi.org/10.1038/s41594-018-0141-6

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