Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation

The Ras-ERK signaling pathway regulates diverse cellular processes in response to environmental stimuli and contains important therapeutic targets for cancer. Recent single cell studies revealed stochastic pulses of ERK activation, the frequency of which determines functional outcomes such as cell p...

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Detalles Bibliográficos
Autores principales: Yang, Jr-Ming, Bhattacharya, Sayak, West-Foyle, Hoku, Hung, Chien-Fu, Wu, T.-C., Iglesias, Pablo A., Huang, Chuan-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220176/
https://www.ncbi.nlm.nih.gov/pubmed/30405112
http://dx.doi.org/10.1038/s41467-018-07150-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220176/
https://www.ncbi.nlm.nih.gov/pubmed/30405112
http://dx.doi.org/10.1038/s41467-018-07150-9

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