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Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation
The Ras-ERK signaling pathway regulates diverse cellular processes in response to environmental stimuli and contains important therapeutic targets for cancer. Recent single cell studies revealed stochastic pulses of ERK activation, the frequency of which determines functional outcomes such as cell p...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220176/ https://www.ncbi.nlm.nih.gov/pubmed/30405112 http://dx.doi.org/10.1038/s41467-018-07150-9 |