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Gene inversion potentiates bacterial evolvability and virulence

Most bacterial genes are encoded on the leading strand, co-orienting the movement of the replication machinery with RNA polymerases. This bias reduces the frequency of detrimental head-on collisions between the two machineries. The negative outcomes of these collisions should lead to selection again...

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Detalles Bibliográficos
Autores principales: Merrikh, Christopher N., Merrikh, Houra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220195/
https://www.ncbi.nlm.nih.gov/pubmed/30405125
http://dx.doi.org/10.1038/s41467-018-07110-3