Dynamic recognition and linkage specificity in K63 di-ubiquitin and TAB2 NZF domain complex

Poly-ubiquitin (poly-Ub) is involved in various cellular processes through the linkage-specific recognition of Ub-binding domains (UBD). In this study, using molecular dynamics (MD) simulation together with an enhanced sampling method, we demonstrated that K63-linked di-Ub recognizes the NZF domain...

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Detalles Bibliográficos
Autores principales: Moritsugu, Kei, Nishi, Hafumi, Inariyama, Keiichi, Kobayashi, Masanori, Kidera, Akinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220233/
https://www.ncbi.nlm.nih.gov/pubmed/30405169
http://dx.doi.org/10.1038/s41598-018-34605-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220233/
https://www.ncbi.nlm.nih.gov/pubmed/30405169
http://dx.doi.org/10.1038/s41598-018-34605-2

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