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Dynamic recognition and linkage specificity in K63 di-ubiquitin and TAB2 NZF domain complex
Poly-ubiquitin (poly-Ub) is involved in various cellular processes through the linkage-specific recognition of Ub-binding domains (UBD). In this study, using molecular dynamics (MD) simulation together with an enhanced sampling method, we demonstrated that K63-linked di-Ub recognizes the NZF domain...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220233/ https://www.ncbi.nlm.nih.gov/pubmed/30405169 http://dx.doi.org/10.1038/s41598-018-34605-2 |